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Vascular disrupting agents

Hinnen P, Eskens FA. (2007) Vascular disrupting agents in clinical development. Br J Cancer 96 1159-1165. [Pg.168]

Salmon HW, Siemann DW. (2006) Effect of the second-generation vascular disrupting agent OXi4503 on tumor vascularity. Clin Cancer Res 12 4090-4094. [Pg.168]

Ombrabulin (AVE8062, AC-7700) 58 (Sanofi-Aventis) is being evaluated in Phase II/III trials as a treatment for advanced stage soft tissue sarcoma for patients who have failed previous anthracycline and ifosfamide treatments.124 Ombrabulin 58125 128 is a synthetic combretastatin analogue that was licensed by Sanofi-Aventis from Ajinomoto and is also a vascular disrupting agent. [Pg.333]

More recently a series of derivatives with nitro or serinamide substituents at the 2 5 or 6 position of Combretastatin A-4 were synthesized via a typical Wittig reaction. Some of them are strong inhibitors of tubulin assembly and vascular disrupting agents [21]. [Pg.86]

In 2014, Mahal and coworkers disclosed their work on the antitumor activities of some quinazolines as tumor vascular-disrupting agents. These compounds were synthesized via direct amination of the tautomerizable heterocycle using BOP in the presence of DBU in MeCN (14CMC847). [Pg.41]

Diketopiperazine-type antimicrotubule and vascular-disrupting agents 13CPB889. [Pg.264]

Cooney MM, Ortiz J, Bukowski RM, et al. Novel vascular targeting/disrupting agents combretastatin A4 phosphate and related oompounds. Curr Onool Rep 2005 7 90-95. [Pg.49]

The primary mechanism of conventional OP-containiiig chemical nerve agents is inhibition of cholinesterase and the concomitant accumulation of ACh. Logically, vascular smooth muscle contractility will be altered if substantially high levels of circulating ACh remain. Freeman et al. (1986) reported that the disruption of ACh signaling... [Pg.381]

See other pages where Vascular disrupting agents is mentioned: [Pg.174]    [Pg.333]    [Pg.39]    [Pg.432]    [Pg.62]    [Pg.237]    [Pg.242]    [Pg.245]    [Pg.256]    [Pg.262]    [Pg.267]    [Pg.267]    [Pg.268]    [Pg.212]    [Pg.174]    [Pg.333]    [Pg.39]    [Pg.432]    [Pg.62]    [Pg.237]    [Pg.242]    [Pg.245]    [Pg.256]    [Pg.262]    [Pg.267]    [Pg.267]    [Pg.268]    [Pg.212]    [Pg.189]    [Pg.1143]    [Pg.525]    [Pg.240]    [Pg.243]    [Pg.249]    [Pg.1932]    [Pg.99]    [Pg.2812]    [Pg.563]    [Pg.278]    [Pg.117]    [Pg.1651]    [Pg.226]    [Pg.748]    [Pg.78]    [Pg.209]    [Pg.149]    [Pg.117]    [Pg.152]    [Pg.246]    [Pg.3222]    [Pg.38]    [Pg.2406]    [Pg.91]   
See also in sourсe #XX -- [ Pg.237 , Pg.262 ]



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Tumor vascular-disrupting agents

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