Vardenafil efficacy

Gresser U, Gleiter CH. Erectile dysfunction comparison of efficacy and side effects of the PDE-5 inhibitors sildenafil, vardenafil and tadalafil review of the literature. Eur J Med Res 2002 7 435-446. 

VARDENAFIL HYDROCHLORIDE 10 mg taken orally approximately 60 minutes before sexual activity. The dose may be increased to a maximum recommended dose of 20 mg or decreased to 5 mg based on efficacy and side effects. The maximum recommended dosing frequency is once daily. Vardenafil can be taken with or without food. 

Renal function impairment In volunteers with severe renal impairment (Ccr 30 mL/min or less), sildenafil clearance was reduced. Consider an initial sildenafil dose of 25 mg in these patients. There is no clinical data on the safety or efficacy of vardenafil in patients with end-stage renal disease requiring dialysis. 

The safety and efficacy of combinations of sildenafil or vardenafil with other treatments for erectile dysfunction have not been studied. Therefore, the use of such combinations is not recommended. 

Porst H, Rosen R, Padma-Nathan H, et al. Efficacy and tolerability of vardenafil, a new selective phosphodiesterase type 5 inhibitor, in patients with erectile dysfunction the first at home clinical trial. IntJ Impot Res 2001 13 192-199. 

PHOSPHODIESTERASE TYPE 5 INHIBITORS (e.g. sildenafil, tadalafil, vardenafil) GRAPEFRUIT JUICE Possibly t efficacy and t adverse effects, e.g. hypotension Small t in bioavailability, t variability in pharmacokinetics, i.e. interindividual variations in metabolism Safest to advise against intake of grapefruit juice for at least 48 hours prior to intending to take any of these preparations. When necessaiy, the starting dose of sildenafil should not exceed 25-50 mg and that of tadalafil 10 mg. Avoid co-administration with vardenafil... 

Comparative studies The efficacy and safety of the three main inhibitors of phosphodiesterase type 5, sildenafil, tadala-fil, and vardenafil have been extensively investigated in clinical trials. However, there is little information about potential... 

---