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Valproic acid during pregnancy

The answer is d. (Katzung, pp 411, 1029.) An increased incidence of spina bifida may occur with the use of valproic acid during pregnancy Cardiovascular, orofacial, and digital abnormalities may also occur. The main issue with the use of phenobarbital or primidone (metabolite is phe-nobarbital) for the fetus is neonatal dependence on barbiturates. [Pg.168]

Rodriguez-Pinilla E, Arroyo I, FondeviUa J, Garcia MJ, Martinez-Frias ML. Prenatal exposure to valproic acid during pregnancy and limb deficiencies a case-control study. Am J Med Genet 2000 90(5) 376-81. [Pg.3592]

The miscellaneous anticonvulsants are contraindicated in patients with known hypersensitivity to any of the dru. Carbamazepine is contraindicated in patients with bone marrow depression or hepatic or renal impairment and during pregnancy (Category D). Valproic acid is not administered to patients with renal impairment or during pregnancy (Category D). Oxcarbazepine (Trileptal), a miscellaneous anticonvulsant, may exacerbate dementia... [Pg.258]

It is best to avoid concomitant use of ivermectin and other drugs that enhance GABA activity, eg, barbiturates, benzodiazepines, and valproic acid. Ivermectin should not be used during pregnancy. Safety in children younger than 5 years has not been established. [Pg.1151]

Iqbal MM, Sohhan T, Mahmud SZ The effects of lithium, valproic acid, and carbamazepine during pregnancy and lactation. J Toxicol Clin Toxicol 2001 39 381. [PMID 11527233]... [Pg.1270]

See other pages where Valproic acid during pregnancy is mentioned: [Pg.94]    [Pg.142]    [Pg.94]    [Pg.142]    [Pg.1997]    [Pg.121]    [Pg.602]    [Pg.596]    [Pg.328]    [Pg.380]    [Pg.382]    [Pg.384]    [Pg.150]    [Pg.583]    [Pg.351]    [Pg.377]    [Pg.3036]    [Pg.287]    [Pg.2092]    [Pg.2806]    [Pg.336]    [Pg.1034]    [Pg.1436]    [Pg.34]    [Pg.40]    [Pg.278]    [Pg.307]    [Pg.288]   
See also in sourсe #XX -- [ Pg.648 ]



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