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Val-Ala-Tyr

It was straightforward to identify the spin systems of four valines, five threonines, four alanines, three glycines, two glutamates, and AMX type residues (Asp, Cys, Phe, Tyr, Trp, and Ser) of this protein from the COSY, RELAY, and NOESY spectra in D O solution. The RELAY spectrum was particularly useful in identification of Val, Ala, Thr, and Glu spin systems. [Pg.298]

HIV-1 resistance to NNRTIs rapidly arises following passage of the virus in cell culture in the presence of the compounds. The 181 Tyr — Cys mutation is most commonly seen, and it leads to resistance, or at least to reduced sensitivity, to most of the NNRTIs (i.e., TIBO, HEPT, nevirapine, pyridinone, BHAP, TSAO, a-APA) [78-84], The 188 Tyr —> His mutation is associated with resistance to TIBO [85], but not nevirapine [82], The 103 Lys —> Asn mutation is associated mainly with resistance to TIBO and pyridinone [78,85], The 100 Leu —> lie mutation is associated mainly with resistance to TIBO [85,86]. The 106 Val —> Ala mutation mainly leads to resistance to nevirapine and HEPT [83,84,87]. The 138 Glu — Lys mutation is responsible for resistance to TSAO [88,89]. The 190 Gly — Glu mutation accounts for resistance to quinoxaline [68], while also leading to a dramatic reduction in RT activity [90] and the 236 Pro — Leu mutation is responsible for resistance to BHAP [91]. [Pg.327]

Fig. 6.28. Breakdown reactions of Val-Tyr-Xaa3-Asp-Xaa5-Ala as a function of pH (Asu = aspartic succinimide) [93] [96], a) Breakdown reactions of Val-Tyr-Pro-Asp-Gly-Ala in pH ranges 1-3, 4-5, and 6-10. b) Breakdown reactions of Val-Tyr-Pro-Asp-Ser-Ala, Val-Tyr-Pro-Asp-Val-Ala, and Val-Tyr-Gly-Asp-Gly-Ala at pH 1. c) Breakdown reactions of the same... Fig. 6.28. Breakdown reactions of Val-Tyr-Xaa3-Asp-Xaa5-Ala as a function of pH (Asu = aspartic succinimide) [93] [96], a) Breakdown reactions of Val-Tyr-Pro-Asp-Gly-Ala in pH ranges 1-3, 4-5, and 6-10. b) Breakdown reactions of Val-Tyr-Pro-Asp-Ser-Ala, Val-Tyr-Pro-Asp-Val-Ala, and Val-Tyr-Gly-Asp-Gly-Ala at pH 1. c) Breakdown reactions of the same...
At pH 10 and 70°, the hexapeptides had tm values for degradation of ca. 30-40 h, with the exception of Val-Tyr-Pro-Asp-Val-Ala, the stability of which was much greater (t1/2 ca. 800 h). Here, the hexapeptides containing Asp-Gly or Asp-Ser were clearly much more reactive than the Asp-Val hexapeptide. Interestingly, the D,L-iso-aspartic hexapeptide was the only product formed from the Asp-Gly hexapeptides, and it was the major product from the Asp-Ser hexapeptide (Fig. 6.28,a and c). Formation of the D-Asp hexapeptide was observed for the Asp-Ser hexapeptide, and it was the major one for the Asp-Val hexapeptide, presumably because base-catalyzed epimerization had ample time to occur given the very slow rate of other breakdown reaction. [Pg.318]

The following articles describe some of the molecular and physical properties of this enzyme [EC 3.4.22.3] which catalyzes the hydrolysis of peptide bonds and exhibits a broad specificity (at Lys-, Ala-, Tyr-, Gly-, Asn-, Leu-, and Val-). [Pg.281]

Fio. 38. Plot of the algorithm of the retention factor, k, and log P, the water-/i>octanol partition coefficient of eight amino acids. The chromatographic data were obtained on 3 ftm LiChrosorb kP-8, 230 x 4.6 mm i.d. eluierit 0.1 M aqueous phosphate buffer, pH 6.7, T 70 C. Eluites Trp, tryptophan Phe, phenylalanine Leu, leudne Val. valine Tyr, tyrosine Lys, lysine Ala, alanine Gly, glycine. Reprinted with permission from Molnar and Horvith QOS). [Pg.140]


See other pages where Val-Ala-Tyr is mentioned: [Pg.293]    [Pg.36]    [Pg.596]    [Pg.596]    [Pg.412]    [Pg.2502]    [Pg.3452]    [Pg.1205]    [Pg.1205]    [Pg.1003]    [Pg.293]    [Pg.36]    [Pg.596]    [Pg.596]    [Pg.412]    [Pg.2502]    [Pg.3452]    [Pg.1205]    [Pg.1205]    [Pg.1003]    [Pg.177]    [Pg.178]    [Pg.182]    [Pg.184]    [Pg.575]    [Pg.576]    [Pg.53]    [Pg.173]    [Pg.173]    [Pg.145]    [Pg.146]    [Pg.146]    [Pg.313]    [Pg.143]    [Pg.243]    [Pg.141]    [Pg.294]    [Pg.313]    [Pg.314]    [Pg.314]    [Pg.314]    [Pg.314]    [Pg.317]    [Pg.181]    [Pg.181]    [Pg.85]    [Pg.10]    [Pg.293]    [Pg.126]    [Pg.126]    [Pg.13]    [Pg.17]    [Pg.43]   
See also in sourсe #XX -- [ Pg.5 , Pg.13 ]




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Receptor binding properties of Tyr-D-Ala-Phe-Asp-Val-ValThr -Gly

Val-Tyr-Pro-Asp-Gly-Ala

Val-Tyr-Pro-Asp-Ser-Ala

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