Vaginal drug delivery liposomes

Pavelic, Z., N.S. Skalko-Basnet, and R. Schubert. 2001. Liposomal gels for vaginal drug delivery. Int J Pharm 219 139. 

The incorporation of drug-loaded liposomes in adequate formulations can improve their stability, allowing their applicability in vaginal drug delivery [151], Additionally, entrapment of drugs in liposomes may improve their solubility and... 

Pavelic Z, Skalko-Basnet N, Schubert R. Liposomal gels for vaginal drug delivery. International Journal of Pharmaceutics. 2001 219(1) 139-149. 

Liposomes, a novel drug delivery system, are widely applied in the topical treatment of diseases, including vaginal diseases. Their applications in contraceptive systems for the intravaginal administration of progesterone and interferon-a (or metronidazole) for the genital papilloma virus infections were previously reported. 

The nonperoral mucosal delivery routes such as buccal, nasal, and vaginal sites offer barriers to drug molecules similar to that of the peroral route. Drugs delivered via these routes have to be small (<300 Da), lipophilic in nature, and with low dosage regimen requirements. The different approaches used to deliver drugs across these mucosae include the use of enzyme inhibitors, penetration enhancers, bioadhesive patches, prodrugs, liposomes, and solubility modifiers.96,106,130... 

---