V-Shell Blender

Perform Installation Qualification. Verify equipment identification, required documents, utilities, manual, and drawings. 

Operate the blender throughout the range of operating design specifications or range of intended use. 

Verify equipment switches, push-buttons, rotation direction, and motor fixed speed. 

Perform the assay to check the content uniformity on blended granules at different locations. 

The system is installed in accordance with design specifications, manufacturer recommendations, and cGMPs. Instruments are calibrated, identified, and entered into the calibration program. 

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A number of different geometries are available from blender manufacturers, including V-blenders (e.g., the twin-shell blender), double cones, rotating cylinders,... 

Effective mixing of solids is also accomplished by rotating the sample for some time in a ball mill or a twin-shell V-blender. The latter consists of two connected cylinders that form a V-shaped container for the sample. As the blender is rotated, the sample is split and recombined with each rotation, leading to highly efficient mixing. 

Porta Shell, Lab size double cone and V blenders, Patterson Process Equipment Div. 

Figure 5.2 Low-intensity mixer designs (a) double-cone blender (b) twin-shell ( V ) blender (c) conical screw mixer (d) conical screw mixer...

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