Utilization of solubilization in drug delivery systems

(b) Effect of concentration of sodium lauryl sulphate on the release of butamben from micellar systems containing 15.5 mg butamben in silicone capsules at 37° C. Sodium lauryl 

Mixed micelle formation and complex formation will achieve similar alterations in the transport properties of drug molecules. When the drug molecules themselves can aggregate, this will result in a reduction in permeability above their critical micelle concentration [221, 223]. 

1 Theoretical considerations of transport and release from solubilized systems 

If the transport rate of the drug is diffusion controlled then the rate of uptake by the oil phase will be equal to the rate of transport through the aqueous phase. The steady-state rate of transport through the aqueous phase to the oil droplet, G, is given by 

Subscripts f = free drug and m = drug in the micelle, as before. Other symbols have their usual meaning h is the diffusion layer thickness. The oil is regarded as a perfect sink and the following relation assumed 

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