Utilization of Chelating Substrates

A chelation-assisted strategy is another useful method for C—C bond cleavage. In this method, the substrates containing a coordinating functional group will first coordinate to a metal and form a stable metallacycle. A representative example of this strategy is the activation of the a-C—C bond to the carbonyl group in 8-quinolinyl alkyl 

The a-C—C bonds adjacent to carbonyls, alcohols, and nitriles are often the targets for activation [92]. This section focuses on recent developments of transition metal-catalyzed C—CN bond cleavage. 

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