Used in Gout

Here also there are two hydrogen atoms in excess, but they are removed by secondary reactions (leading to the formation of hydrogenated products). The well-known drug atophan (used in gout),... 

Colchicine, an alkaloid obtained from the autumn crocus, has long been used and is relatively selective for the treatment of acute gouty arthritis. Unlike many of the newer agents for use in gout, colchicine has minimal effects on uric acid synthesis and excretion it decreases inflammation associated with this disorder. It is thought that colchicine somehow prevents the release of the chemotactic factors and/or inflammatory cytokines from the neutrophils, and this in turn decreases the attraction of more neutrophils into the affected area (Fig. 37.1).The ability of colchicine to bind to leukocyte microtubules in a reversible covalent complex and cause their depolymerization also may be a factor in decreasing the attraction of the motile leukocytes into the inflamed area. 

Chapter 36 Nonsteroidal Anti-Inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, Nonopioid Analgesics, Drugs Used in Gout... 

NONSTEROIDAL ANTI-INFLAMMATORY DRUGS, DISEASE-MODIFYING ANTIRHEUMATIC DRUGS, NONOPIOID ANALGESICS, DRUGS USED IN GOUT INTRODUCTION THE IMMUNE RESPONSE... 

Oxaprozin is another propionic acid derivative NSAID. As noted in Table 36-1, its major difference from the other members of this subgroup is a very long half-life (50-60 hours), although oxaprozin does not undergo enterohepatic circulation. It is mildly uricosuric, making it potentially more useful in gout than some other NSAIDs. The drug has the same benefits and risks that are associated with other NSAIDs. 

AccessMedicine Print Chapter 36. Nonsteroidal Anti-Inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, Nonopioid Analgesics, Drugs Used in Gout Acute pain and fever may be effectively treated with 325-500 mg four times daily and proportionately less for children. 

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