Use of Antisolvent

Antisolvents can be used in three ways (1) to create supersaturation in an isothermal process, (2) to decrease the solubility at the end of a cooling crystallization to increase yield, and (3) simply to modify, to decrease the solubility of moiety. 

In some cases, it is necessary to add antisolvent in order to increase the yield of the crystallization processes. There is a risk of spontaneous nucleation around the location of the addition of the antisolvent in the reactor because there supersaturation reaches its maximum values. 

In the light of these potential issues, it is advised to limit the addition of antisolvents whenever possible. In some cases, it is overseen that the antisolvent that is added to 

Drowning-out is a term sometimes used for fast antisolvent addition resulting in high supersaturations that lead to high nudeation rates. This variant is described in 

Evaporative crystallization is a technique of choice for a moiety with a weak dependence of solubility on temperature. However, this technique has several drawbacks that should be regarded when using this technique. 

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Supercritical antisolvent and related processes (GAS/SAS/ASES/SEDS). Precipitation using SCFs as non-solvents or antisolvents utilizes a similar concept to the use of antisolvents in solvent-based crystallization processes. 

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