Use in morning sickness

Pyridoxine is used in morning sickness. Its mechanism of action remains unclear and several reviews of the use of pyridoxine have failed to find conclusive evidence of effectiveness. A recent double blind trial found pyridoxine to be of benefit in reducing nausea only. Some clinicians use pyridoxine as the first drug on the basis that it is the least likely to be toxic to the foetus. 

As an antiemetic in drug and disease induced vomiting. Also useful in morning sickness but are ineffective in motion sickness. 

It has got antispasmodic with direct smooth muscle relaxant action. It is used in morning and motion sickness. 

Cardamom essential oil traditionally has been used as a tonic to the digestive system, as well as a component of many sensual aphrodisiac blends. The oil has the aroma of freshly dried cardamom pods, far superior to the comparatively flat steam-distilled variety of this oil. Cardamom oil may relieve spasm, possibly making it beneficial for colitis, irritable bowel syndrome, indigestion and cramps. It may be of benefit where the digestive system is affected by nervous tension. In addition, cardamom oil can relieve nausea and may be useful for morning sickness in pregnancy. 

A number of clinical trials and epidemiological studies evaluating the use of ginger in morning sickness have been completed. A systematic review of randomized controlled... 

Thalidomide used to alleviate the symptoms of morning sickness in pregnant women before 1963. 

Several Hi antagonist drugs have been studied for possible use in treating "morning sickness." The piperazine derivatives were withdrawn from such use when it was demonstrated that they have teratogenic effects in rodents. Doxylamine, an ethanolamine Hi antagonist, was promoted for this application as a component of Bendectin, a prescription medication that also contained pyridoxine. Possible teratogenic effects of doxylamine were widely publicized in the lay press after 1978 as a... 

Thalidomide was used to treat morning sickness in the late 1950s, but was soon discovered to have caused a number of birth defects. For a time it was believed that the birth defects were due to one enantiomer of this drug and that the other enantiomer was harmless. However, it was later found that either enantiomer will racemize under the acidic conditions of the stomach so the harmless enantiomer is converted to the harmful one. Suggest a mechanism for this racemization. 

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