US NTP Expert Panel conclusions

Ejqrert Panel conclusions are summarized in Table 17.4.2. Since primates showed no testis effects when exposed to DEHP at oral doses similar to those which wonld cause testicular toxicity in juvenile rodents, the Expert Panel has a minimal concern that ambient human exposures adversely affect adult httman reproduction However, exposure of healthy infants and toddlers, whose reproductive systems are still developing, is more of concern. Thus, if an infant or toddler is ejqrosed to levels higher than that expected with ambient adult exposiue, the Expert Panel has concern that exposure may adversely affect male reproductive tract development. Because it is possible that exposures of critically ill male infants who are exposed via medical therapy can approach doses that are toxic in rodent models, the Expert Panel has serious concern that such exposure may adversely affect male reproductive tract development. Because oral exposure for humans is estimated at 30 tg/kg bw/day and toxic effects are observed in rodents at 3 mg/kg bw/day, the Expert Panel has concern that ambient oral DEHP exposures of pregnant or lactating women may adversely affect the development of their offspring. 

Phthalate Level of concern Toxicity Population at risk 

Based on data available, the Expert Panel corrcludes that oral exposure to BBP can cause developmental toxicity irr rats and mice, and reproductive toxicity in rats. Due to the low exposures expected to occur in adults in the general population (2 g/kg bw/day) and the high dose identified as the NOAEL (182-185 mg/kg bw/day), the expert panel concluded that there is negligible concern for male reproductive effects from adult expo- 

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