Urine sebacic acid

Polyanhydrides, such as poly[bis(p-carboxyphenoxy)propane sebacic acid] copolymers (Figure 4.14), are also used for the fabrication of biodegradable implants. Polymer degradation occurs via hydrolysis, the biscarboxyphenoxypropane monomer is excreted in the urine and the sebacic acid monomer is metabolized by the liver and is expired as carbon dioxide via the lung (Figure 4.14). 

Fig. 14.5 Chromatogram of organic acids extracted using diethyl ether and ethyl acetate from the urine of a patient with suberylglycinuria and separated as their methyl derivatives (diazomethane) on 3 per cent SE-30 on Chromosorb W (DMCS, 80-100 mesh) using temperature programming from 80°C to 250°C at 6°C min Peak identifications are 1, 3-hydroxybutyrate 2, adipate 3, 3-methyladipate 4, pimelate (heptanedioate) 5, octenedioate 6, suberate (octanedioate) 7, hexanoylglycine plus 4-hydroxyphenylacetate 8, azeleate (nonanedioate) 9, decenedioate 10, sebacate (decanedioate) 11, hippurate 12, unknown, 13, suberylglycine. (Redrawn with modifications from Truscott et al., 1979)...

Fig. 14.7 Chromatogram of organic acids extracted using ethyl acetate and diethyl ether from the urine of a child with Jamaican vomiting sickness, separated as their methyl derivatives (diazomethane) on 5 per cent OV-1 using temperature programming from 70°C to 300°C at 4°C min with a 4 min initial isothermal delay. Peak identifications are 1, 3-hydroxybutyrate plus 3-hydroxyisovalerate (approx. 4 6) 2, ethylmalonate 3, methylsuccinate 4, octanoate 5, glutarate 6, adipate 7, isovalerylglycine 8, 4-octenedioate plus furandicarboxylate 9, suberate (octanedioate) 10, /i-hexanoyl-glycine 11, decenedioate 12, sebacate (decanedioate) 13, hippurate 14, n-pentadecanoate (internal standard) 15, palmitate 16, stearate. (Redrawn with modifications from Tanaka et al, 1976)...

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