Urine retention atropine

Diphenoxylate + Atropine (Lomotil, Lonox) [C V] [Opioid Antidiarrheal] Uses D Action Constipating m CTidine congener, X GI motihty Dose Adults. Initial, 5 mg PO tid—qid until controlled, then 2.5-5 mg PO bid 20 mg/d max Peds >2 y. 0.3-0.4 mg/kg/24 h (of diphenoxylate) bid-qid, 10 mg/d max Caution [C, +] Contra Obstructive jaundice, D d/t bacterial Infxn children <2 y Disp Tabs, Liq SE Drowsiness, dizziness, xCTostomia, blurred vision, urinary retention, constipation Interactions T Effects W/ CNS depressants, opioids, EtOH, T risk HTN crisis W7 MAOIs EMS Monitor for Sxs of electrolyte disturbances and hypovolemia d/t D OD May cause Szs, hypotension, and anticholinergic effects (xerostomia [dry mouth], urine retention, flushed skin) activated charcoal may be effective for OD... 

Atropine also produces reduction in normal and drug induced ureteral peristalsis. It also tends to reduce the tone of the fundus of urinary bladder and enhances the tone of trigonal sphincter and may cause of retention of urine. 

A 39-year-old man who was a recreational user of alcohol and cocaine presented with agitation, hallucinations, and delirium. He had a dry flushed skin, tachycardia, dilated, minimally reactive pupils, urinary retention, and absent bowel sounds. He was treated with intravenous fluids and a sedative. There were cocaine metabolites in the urine. Reanalysis of a urine sample by thin layer chromatography confirmed the presence of the anticholinergic drug atropine. 

Whelpton, R. Hurst, P.R. Metcalfe, R.F. Saunders, S.A. Liquid chromatographic determination of hy-oscine (scopolamine) in urine using solid phase extraction. Biomed.Chromatogr, 1992, 6, 198-204 Achari, R.G. Jacob, J.T. A study of the retention behavior of some basic drug substances by ion-pair HPLC. J.Liq.Chromatogr., 1980, 3, 81-92 [also N-acetylprocainamide, antazoline, atropine, caffeine, chlorpheniramine, codeine, ephedrine, epinephrine, naphazoline, papaverine, pheniramine, phenylephrine, phenylpropanolamine, procainamide, quinidine, xylocaine]... 

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