Urine fibrinolytic activator

Gliclazide is slowly absorbed. It is metabolized and excreted in the urine, in part as unchanged drug with an elimination half-life of 6-14 hours. Its duration of action is about 12 hours. Glicazide reduces platelet adhesiveness and increases fibrinolytic activity. This could be of importance as both factors have been implicated in the pathogenesis of the longterm organ failure in diabetes. 

---