Urinary tract nephrotoxicity, aminoglycosides

Uses Infxns of the resp tract, skin, bone, urinary tract Action 3rd-gen cephalosporin -1- cell wall synth Dose Adults. 400 mg PO daily-bid Peds. 8-20 mg/kg/d PO daily—bid -1- in renal impair Caution [B, +] Contra Cephalosporin allergy Disp Susp SE N/V/D, flatulence, abd pain Interactions t Nqjhrotox W/ aminoglycosides, loop diuretics t effects W/ nifedipine, probenecid EMS t Risk of nephrotox w/ loop diuretics monitor for signs of electrolyte disturbances and hypovolemia d/t D monitor pt for super Infxn OD May cause N/V/D, Szs, muscles spasms symptomatic and supportive... 

Urinary tract In 306 consecutive patients starting aminoglycoside therapy in an ITU-independent susceptibility factors for aminoglycoside-associated nephrotoxicity were a baseline estimated glomerular filtration rate (eGFR) under 60 mFminute/ 1.73 m, diabetes mellitus, treatment with other nephrotoxic drugs or iodinated contrast agents, and hypotension [5 ]. 

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