Urinary acid excretion methodology

Adversed nutritional effects of high doses of ascorbic acid have been reported to lover vitamin 8 2 levels (Hines, 1975 Herbert and Jacob, 1974 Herbert, 1980). In contrast, others (Nevmark and Schelner, 1976) have suggested that methodology problems explain the vitamin 6 2 to ascorbic acid Interaction. Ascorbic acid has also been reported to elevate the excretion of urinary 4-pyridoxic acid, the major metabolite of vitamin Bg (Scllvanova, 1960). Other Interactions between ascorbic acid and vitamin Bg have also been reported (Baker et al, 1971 Baker et al, 1964). More recently, Shultz and Leklem (1982) concluded that short-term ascorbic acid supplementation did not alter vitamin Bg metabolism. 

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