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Uridine Diphosphate Glucuronosyltransferase UGT

Nicotine glucmonidation results in an N-quatemary glucmonide in humans (Benowitz et al. 1994). This reaction is catalyzed by uridine diphosphate-glucuronosyltransferase (UGT) enzyme(s) producing (5)-nicotine-N-P-glucmonide. About 3-5% of nicotine is converted to nicotine glucuronide and excreted in urine in humans. [Pg.36]

O Dwyer PJ, Catalano RB. Uridine diphosphate glucuronosyltransferase (UGT) lAl and irinotecan practical pharmacogenomics arrives in cancer therapy. J Clin Oncol 2006 24(28) 4534-8. [Pg.82]

Tacrolimus may inhibit uridine diphosphate glucuronosyltransferase (UGT) which metabolises mycophenolic acid to the glucuronide metabolite, - and may also interfere with the enterohepatic recycling of the glucuronide metabolite. ... [Pg.1067]

Figure 4 Fluxes and fates of chrysin (Chr) in the human enterocyte monolayer model Caco-2. G, glucuronide conjugate S, sulfate conjugate UGT, uridine diphosphate-glucuronosyltransferase SUIT, sulfotransferase. Figure 4 Fluxes and fates of chrysin (Chr) in the human enterocyte monolayer model Caco-2. G, glucuronide conjugate S, sulfate conjugate UGT, uridine diphosphate-glucuronosyltransferase SUIT, sulfotransferase.
There is a growing number of published examples of the utility of screening patients for pharmacogenetic markers prior to chemotherapy selection (1). Many published markers of association with chemotherapy outcome or toxicity still require validation in prospective studies. Examples of well-characterized pharmacogenetic markers include thiopurine methyltransferase (TPMT), UGT (uridine diphosphate [UDP]-glucuronosyltransferase) lAl, and epidermal growth factor receptor (EGER). [Pg.438]

Liver-kidney microsomal antibodies (LKM). Autoantibodies directed against cytochrome P450 and uridine diphosphate (UDP)-glucuronosyltransferase (UGT) antigens typically found in patients... [Pg.242]

See other pages where Uridine Diphosphate Glucuronosyltransferase UGT is mentioned: [Pg.43]    [Pg.502]    [Pg.59]    [Pg.734]    [Pg.192]    [Pg.12]    [Pg.886]    [Pg.1415]    [Pg.191]    [Pg.45]    [Pg.43]    [Pg.502]    [Pg.59]    [Pg.734]    [Pg.192]    [Pg.12]    [Pg.886]    [Pg.1415]    [Pg.191]    [Pg.45]    [Pg.63]    [Pg.3455]    [Pg.39]    [Pg.427]    [Pg.87]    [Pg.156]    [Pg.349]    [Pg.256]    [Pg.361]    [Pg.377]    [Pg.29]   


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Glucuronosyltransferase

Glucuronosyltransferases

UGTs

UGTs (uridine

Uridine diphosphate glucuronosyltransferases

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