Uric acid diathesis

But as frustrating as Haig s inattention to these frequent scoldings could be, uric acid critics were more bothered by the naivete of rank and file physicians, so many of whom, it was charged, had allowed themselves to be conditioned to reflexly diagnose "uric acid diathesis" if any uric acid were found in the patient s urine. That the compound had been able to acquire what one commentator described as a "fixed hold" on the medical profession should not, however, have caused much surprise. (40)... 

Lithium urates.—The acid salt, CsH3N40jLi, is formed by dissolving uric acid in a warm solution of lithium carbonate. It crystallizes in needles, which dissolve in 60 parts of HaO at 50° (122° F.) and do not separate when the solution is cooled. It is partly with a view to the formation of this, the most soluble of the acid urates, that the compounds of lithium are given to patients suffering with the uric acid diathesis. 

Fig. 1 shows how much the solubility of uric acid depends upon the pH value. For the so-called idiopathic uric-acid-stone-diathesis without hyperuricemia and hyperuricos-uria, the only characteristic clinical indication is the low pH of between 4.8 and 5.5 compared to the normal values of healthy persons of 5.7 to 6.3 - this is in cases when there is no stone formation. The relative continuity of the acidity of the urine — which according to investigations by Atsmon, Gutman, and Sperling is caused by a... 

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