Uraemic coma

Uraemic coma is a condition produced when excessive by-products of protein metabolism (e.g. urea) are accumulated in the blood. It occurs when the kidney nephron function is inadequate at coping with excretion of urea and related compounds. It has been proposed by Sen [1839-1841 ] that the underlying cause for uraemic coma is the generation of... 

Sen [1839-1841] further suggested that the ammonia formed enters the ornithine cycle and that the phosgene creates uraemic coma (although he offers no rationalization for this suggestion). On both chemical and medical grounds, these papers merit no serious consideration. 

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