Unpublished References

Incidentally, most FDA submissions permit unpublished as well as published references. Supporting letters, studies not yet in print, copies of speeches and papers, and other unpublished references can be included. Refer as with any other document and include a copy in the reference section. 

Substantial amounts of polymalatase have been isolated from plasmodial extracts. This may refer to stored enzyme before secretion, because /3-poly(L-malate) is not degraded in plasmodia [24]. Several other fungi were found to secrete /3-poly(L-malate) degrading activities to L-malic acid (Ratberger, Molitoris and Holler, unpublished results). These enzymes have not yet been purified and characterized. 

Because Carnot s 1824 manuscript remained unpublished at the time of his death m 1832, it was left to Kelvin and Rudolf Clausius to show how the second law of thermodynamics was implicit in Carnot s work. For this reason Kelvin once referred to Carnot as the profoundest thinker in thermodynamic philosopihy in the first thirty years of the nineteenth century. ... 

SOMe the enhancement in the meta-position is almost as large as in the para-position. The authors go on to show the applicability of op (g) values to certain solution processes, particularly those in non-aqueous solvents, but including the dissociation of thiophenols in 48% ethanol, the results of Bordwell and Andersen80 to which reference has been made earlier (Section III.A.1). A separation of field/inductive and resonance effects is also essayed for the gas-phase acidities of the phenols, and SOMe and S02Me feature in the discussion. There is reference to a oR° value of + 0.07 for SOMe as an unpublished result of Adcock, Bromilow and Taft (cf. 0.00 from Ehrenson and coworkers65 and — 0.07 from Katritzky, Topsom and colleagues128.)... 

The authors have borrowed from existing open literature and patent sources and all pertinent references are given at the back of the chapter. Where appropriate, they have included previously unpublished data from their own laboratories. 

J. King and N. Davidson, unpublished data quoted in Reference 545. 

Pawlik, R. T, Bray, R. C. Unpublished observations cited in reference 20. 

Wolbachia endosymbionts are abundant in arthropods, where they promote a variety of reproductive manipulations, including feminization of genetic males, parthenogenesis and cytoplasmic incompatibility. Wolbachia is also present in filarial nematodes and has recently attracted a great deal of attention. This chapter reviews the studies so far published and discusses potential implications and future research prospects. Since this is a relatively young field, the chapter will also refer to unpublished studies and will include some speculation. The aim is to stimulate further work on the subject. 

Pt and Au data are from unpublished work of F. Asaro, H. V. Michel, W. Alvarez, and L. W. Alvarez, 1980. The others were published in reference 1. 

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