Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Uniquely Inhibitable Kinases inhibitor

To date, the only MEK 1/2 kinase inhibitors to enter clinical development have shown inhibition that is not ATP competitive. This unique mechanism of inhibition of MEKl/2 has enabled compounds such as ARRY-142886 and PD0325901 to achieve excellent enzymatic and cellular selectivity for, and potency against, MEK 1/2. [Pg.93]

Inasmuch as VASP appears to be localized to focal adhesions in intact platelets, the interesting possibility exists that PKG regulates focal adhesion assembly. In a report by Murphy-Ullrich and coworkers (1994), selective inhibitors of PKG, but not PKA or protein kinase C, inhibited thrombospondin-evoked focal adhesion disassembly, suggesting that PKG mediates thrombospondin action. This would be a new role for PKG in regulating cellular shape and motility. The role of VASP in this process is currently unknown, but the availability of cDNA probes for controlling expression of this unique protein may provide answers. [Pg.266]

See other pages where Uniquely Inhibitable Kinases inhibitor is mentioned: [Pg.1261]    [Pg.160]    [Pg.585]    [Pg.42]    [Pg.214]    [Pg.1261]    [Pg.331]    [Pg.534]    [Pg.173]    [Pg.219]    [Pg.33]    [Pg.193]    [Pg.25]    [Pg.22]    [Pg.56]    [Pg.18]    [Pg.410]    [Pg.23]    [Pg.415]    [Pg.653]    [Pg.45]    [Pg.278]    [Pg.221]    [Pg.84]    [Pg.65]    [Pg.66]    [Pg.69]    [Pg.74]    [Pg.612]    [Pg.156]    [Pg.401]    [Pg.254]    [Pg.141]    [Pg.955]    [Pg.411]    [Pg.896]    [Pg.1773]    [Pg.307]    [Pg.27]    [Pg.11]   


SEARCH



INHIBITION INHIBITOR

Kinase inhibition

Kinase inhibition, inhibitors

Kinase inhibitors

Kinase, kinases inhibitors

UniQuant

Unique

Uniqueness

© 2024 chempedia.info