Ultrasonic therapy tumors

Preclinical trials of the method of solid-phase sonosensitization were carried out at N.N. Blokhin Russian Research Oncological Center. The experiments included estimation of the therapeutic efficiency, harmlessness, and the effect on metastatic disease. These studies showed a high therapeutic efficiency of the method, that is, tumor regression by 75-80% on average with an increase in the animal lifetime by a factor to 2, good exposure tolerance, and the absence of the effect on metastatic disease. Currently, the method of ultrasonic therapy with solid-phase sonosonosensitizers is in clinical trials. 

R.H. Simon, S.Y. Ho, D.F. Uphoff, S.C. Lange and J.S. D Arrigo, Applications of lipid-coated microbubble ultrasonic contrast to tumor therapy, Ultrasound Med. Biol. 19 (1993) 123-125. 

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