Ultrarapid Approaches to Mild Macromolecular Conjugation

Preparative Macromolecular Chemistry, Karlsruhe Institute of Technology (KIT), Engesserstrafie 18, Get. 11.23, 76128 Karlsruhe, Germany 

Although the use of such processes as atom-transfer radical polymerization (ATRP) (Ouchi et al, 2009 Braunecker and Matyjaszewski, 2007) and reversible addition-fragmentation chain transfer (RAFT) polymerization (Moad et al, 2009 Moad et al, 2008) have been exploited in and of themselves in producing well-defined architectures it has only been with 

Complex Macromolecular Architectures Synthesis, Characterization, and Self-Assembly, First Edition. 

Edited by Nikos Hadjichristidis, Akira Hirao, Yasuyuki Tezuka and Filip Du Prez. 

To this end, the principal aim of this chapter is to highlight those conjugation chemistries which either have been (or have the potential to be) highly useful in the field of mild, ultrarapid macromolecular conjugation. That is not to say that every reaction presented herein may be labeled as a click reaction for, as will be shown, some examples fail the orthogonality criterion. Not qualifying as click chemistry does not, and should not be inferred to mean useless. 

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Figure 2.2 Overview of ultrarapid and mild conjugation chemistries. (Reproduced with permission from A.J. Inglis and C. Earner-Kowollik, Ultra rapid approaches to mild macromolecular conjugation, Macromolecular Rapid Communications, 2010, 31,14,1247-1266. Wiley-VCH Verlag GmbH Co. KGaA.)...

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