Ultrahigh-Throughput Screening

Bialkowska A.B. Crisp M. Bannister T. He Y. Chowdhury S. Schurer S. Chase P. Spicer T. Madoux F. Tian C. Hodder P. Zaharevitz D. Yang, V.W. Identification of small-molecule inhibitors of the colorectal cancer oncogene Kriippel-like factor 5 expression by ultrahigh-throughput screening. Molecular Cancer Therapeutics, 2011, 10, 2043-2051. 

Figure 6.12 The positive ion ESI-MS and MS/MS product ion spectra of a compound released from a single bead after ultrahigh throughput screening. (Reprinted with permission from Blom et al., 1998. Copyright 1998 John Wiley Sons.)...

Agresti JJ etal (2010) Ultrahigh-throughput screening in drop-based microfluidics for directed evolution. Proc Natl Acad Sci U S A 107 4004... 

Wakarchuk, W.W., Eeng, Y., and Withers, S.G. (2010) Fluorescence activated cell sorting as a general ultrahigh-throughput screening method for directed evolution of glycosyltransferases. J. Am. Chem. Soc., 132, 10570-10577. 

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