Ugi Reactions Investigated in Micro Reactors

Oiganic synthesis 65 [OS 65] 4CC reaction between aldehyde, primary amine, acid and isocyanide 

Methyl 4-formylbenzoate, benzylamine, 2-nitrobenzoic acid, and cyclohexyl isocyanide were converted to the corresponding 4CC Ugi adduct [16], 

Oiganic synthesis [OS 66] Ugi reaction between aldehyde, secondary amine salt and isocyanide 

Formaldehyde was used the exact nature of the secondary amine salt and isocyanide were not disclosed. The corresponding a-dialkylacetamide was obtained [25]. 

A further summary of the many decades of achievement of the Ugi chemistry has been given [132], 

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Addition to Carbon-Hetero Multiple Bonds 513 4.9.1.3 Ugi Reactions Investigated in Micro Reactors... 

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