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UDP-glucuronyltransferase UGT

Glucuronidation is an important detoxification pathway in humans. Many therapeutic drugs and their metabolites are substrates for UDP-glucuronyltransferase (UGT), leading to the formation of usually inactive glucuronides, which are then excreted via bile or urine. Individual UGT enzymes are defined in a similar way to the GYP enzymes by family (1 or 2), subfamily (A or B) and an Arabic numeral representing the... [Pg.121]

Less is known about the enzymes responsible for phase II conjugation reactions. However, UDP-glucuronyltransferases (UGT), methyltrans-ferases, and N-acelyltransferases (NAT) are examples. [Pg.4]

See other pages where UDP-glucuronyltransferase UGT is mentioned: [Pg.126]    [Pg.26]    [Pg.55]    [Pg.206]    [Pg.126]    [Pg.26]    [Pg.55]    [Pg.206]    [Pg.218]    [Pg.333]   


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