Ubiquitin-conjugating enzyme variant

The CSN3 subunit interacts with IKKy, a component of the IsrB-kinase complex controlling NF-kB activity [32]. Additionally, it is the binding site for the CSN-associated kinases CK2 and PKD [31]. The subunit of the translation-initiation factor 3 complex, Int6/eIF3e, and the ubiquitin-conjugating enzyme variant, COPIO, have been identified as other cellular interactors [33, 34]. Also the HIV-1 Tat protein interacts with CSN 3 (our unpublished data). 

Arabidopsis COPIO is a ubiquitin-conjugating enzyme variant that acts together with COPl and the COP9 signalosome in repressing photomorphogenesis. Genes Dev. 2002, 36, 554-559. 

ViUalobo, E., Morin, L., Moch, C., Lescasse, R., Hanna, M., Xiao, W., and Baroin-Tourancheau, A. (2002). A homologue of CROC-1 in a ciliated protist (Sterkielia histriomuscorum) testifies to the ancient origin of the ubiquitin-conjugating enzyme variant family. Mol. Biol. Evol. 19, 39-48. 

The second instance of ubiquitin conjugation in PRR involves an atypical poly-Ub chain and a novel mechanism of catalysis employing a Ubc enzyme variant (Uev), Mms2. The MMS2 gene was isolated by functional... 

---