Tyrosine recombinase family

Tyrosine recombinases of the lambda family also function in eukaryotes. Best known is the FLP (Flip) recombinase, which is encoded by the 2-pm plasmid of Saccharomyces cerevisiae and is thought to function in amplifying the number of plasmid copies.265 The 6.3-kbp plasmid contains a unique DNA sequence that lies between two 599-bp repeats in inverted orientation. Embedded in each repeat is an FLP recombination target (FRT) sequence, which is recognized by the plasmid recombinase. Each FRT segment includes inverted repeats 13 bp in length with an 8-bp spacer between them. As with other integrase systems the... 

Tyrosine recombinases of the lambda family also fimction in eukaryotes. Best known is the FLP (Flip) recombinase, which is encoded by the 2-pm plasmid of Saccharomyces cerevisiae and is thought to fimction in amplifying the number of plasmid copies. The... 

Esposito, D. and Scocca, J. J. (1997) The integrase family of tyrosine recombinases evolution of a conserved active site domain. Nucleic Acids Res 25,3605—3614. 

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