Tyrosine classification

Synonyms a-Amino-p-hydroxyhydrocinnamic acid L-a-Amino-p-(4-hydroxyphenyl) propionic acid (S)-2-Amino-3-(4-hydroxyphenyl) propionic acid 3-(4-Hydroxyphenyl) alanine I-P-(p-Hydroxyphenyl) alanine Tyrosine l-p-Tyrosine p-Tyrosine Classification Nonessential amino acid Definition Avail, commercially as the naturally occurring L(-)-enantiomer Empirical C9H11NO3... 

Protein Phosphatases. Figure 3 Classification of protein tyrosine phosphatases. See text for details. Common names for selected PTPs are used according to Ref. [2]. 

A machine-learning method was proposed by Klon et al. [104] as an alternative form of consensus scoring. The method proved unsuccessful for PKB, but showed promise for the phosphatase PTPIB (protein tyrosine phosphatase IB). In this approach, compounds were first docked into the receptor and scored using conventional means. The top scoring compounds were then assumed to be active and used to build a naive Bayes classification model, all compounds were subsequently re-scored and ranked using the model. The method is heavily dependent upon predicting accurate binding... 

S. N. Khrapunov and A. I. Dragan, Spectroscopy of molecular interactions of tyrosine chromophore. III. Classification of the state of tyrosine residues in protein composition according to their electronic spectra, Biofizika 34, 357-363 (1989). 

These copper ion-dependent enzymes [EC 1.10.3.1] (also referred to as diphenol oxidases, O-diphenolase, phe-nolases, polyphenol oxidases, or tyrosinases) catalyze the reaction of two catechol molecules with dioxygen to produce two 1,2-benzoquinone and two water. A variety of substituted catechols can act as substrates. Many of the enzymes listed under this classification also catalyze a monophenol monooxygenase activity [/.c., EC 1.14.18.1]. See also Monophenol Monooxygenase Tyrosine Monooxygenase... 

This copper-dependent enzyme [EC 1.14.18.1] (also known as tyrosinase, phenolase, monophenol oxidase, and cresolase) catalyzes the reaction of L-tyrosine with L-dopa and dioxygen to produce L-dopa, dopaquinone, and water. This classification actually represents a set of copper proteins that also catalyze the reaction of catechol oxidase [EC 1.10.3.1] if only 1,2-benzenediols are available as substrates. 

The side chains of the amino acids do not form a natural series, and thus, there is no easy way to learn their structures. It is useful to classify them according to whether they are polar or nonpolar, aromatic or aliphatic, or acidic or basic, although these classifications are not mutually exclusive. Tyrosine, for example, can be considered to be both aromatic and polar, although the polarity introduced by a single hydroxyl group in this aromatic compound is somewhat feeble. 

Patankar, S.J. and Jurs, P.C. (2003b) Classification of inhibitors of protein tyrosine phosphatase IB using molecular structure based descriptors. 

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