Type II allergy

In a number of cases the reason for blood cell deficiency is unknown. It is then referred to as spontaneous, idiopathic. Perhaps more detailed diagnostic methods will solve the problem. 

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According to the Gell and Coombs classification, allergy Type II is called antibody-mediated cytotoxicity . It is triggered by excessive destruction of... 

Immunosuppression can cause a reduction of the animal s resistance to infection and, under certain conditions, also to an increased susceptibility to tumorigenesis (tumor-promotion). In contrast, hyperactivity of the immune system can result in autoimmune diseases or increase the sensitivity to allergies. While it is difficult to identify the mechanisms of the effect(s) of immuno-toxicity it is relatively easy to detect such properties. Information can be provided by investigating special parameters from the rat used in short-term or sub chronic rodent studies (type I tests) (FDA/FDCA 1993). The other category of tests uses in vitro techniques (type II tests). 

Localized food allergies, atopy, and asthma 2. Type II hypersensitivity (cytotoxic type)... 

Toluenediisocyanate Allergy (type I), hypersensitivity reactions (type II)... 

Type I responses and Type II responses have the same consequences, but the mechanisms are different. Type I responses are best known as hay fever and dust allergies and are immune responses to these antigens mediated by a skin fixing antibody (IgE). 

Type II responses involve the reaction of IgG, rarely IgM, antibody with a cell surface antigen. The result is lysis of the cell with release of products. If the cell contains vasoactive amines, then the consequences are signs and symptoms described here. This is commonly seen in allergies to drugs which bind to blood platelets. 

In Frullania, twenty-five taxa have been investigated chemically (27,34). Fourteen species contained allergy-inducing sesquiterpene lactones such as (322, 338, 339, 345, 349). Eighteen species bibenzyl derivatives (595—598, 600—608). The major constituents are sesquiterpene lactones and bibenzyls, which may be valuable chemosystematic markers of Frullania species. Frullania species are divided into five chemotypes, a sesquiterpene lactone-bibenzyl type (Type I), a sesquiterpene lactone-type (Type II), a bibenzyl-type (Type III), a monoterpene-type (Type IV) and a cyclocolorenone (38)-type (Type V). Except for the cyclocolenone-type, there is no chemical affinity between the Frullaniaceae and the Porellaceae. 

Cytotoxic (Type II) Hypersensitivity Type of allergy elicited by antigens on cells, especially red blood cells, that the immune system treats are foreign. 

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