Two-tip Electrospray Device

4 Applications of Two-tip Electrospray Device in Quantitative MS Determination of Methylphenidate Concentration in Urine 

We further investigated the utilization and performance of parylene electrospray tips integrated with cyclo-olefin microchips for quantitative mass spectro-metric determination of the small drug molecule methylphenidate (Ritalin). 

The fabrication procedure for the two-tip device is basically the same as the single electrospray device. First, the two independent microchannels were hot embossed onto one cyclo-olefin polymer chip, and the two sample reservoir holes were drilled onto this cyclo-olefin chip at the end of the microchannels. Then, a gold electrode with a width of 500 pm was fabricated onto another cyclo-olefin chip. A hole for gold electrode access was drilled through the other 

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Figure 6.11 Two-tip electrospray device (A) device design (B) picture of the device.

Figure 6.12 Experimental configuration for interfacing a two-tip electrospray device to an API-Ill plus triple quadrupole mass spectrometer (not drawn to scale).

A calibration curve was prepared by analyzing the prepared calibration standards using a two-tip electrospray device. The calibration standards were prepared by spiking methylphenidate at known concentrations to a negative... 

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