Two Examples of Protein NMR

Some of these programs are conunercially available, such as Delphi for calculations and Insight 98 for drawings. The final step is the construction of the spacefilling model, which is also produced by computer programs such as Insight 98. 

All the spectra and all the analyses can be processed with programs such as NMR Pipe (2) and NMR View software. 

Since 1994, there has been an avalanche of new three-dimensional protein structure determinations, currently at a rate of about 55 per week. Here, we illustrate two 

FIGURE 19.18 See color insert. A membrane protein (a) ribbon diagram (b) recognition (c) interaction. [Source Kuteteladze, et al., Science 291, 1793 (2001). With permission from A A AS. Original in color. 

FIGURE 19.19 See color insert. NMR molecular modeling of prions (a) NMR structure of PrP (b) binding of protein x to PrP° (c) plausible model for the tertiary structure of PrR . Color codes are red, Si green, S2 gray, a-helices H3 and H4 yellow, loop. Four residues 

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