Two-block PLS and indirect QSAR

Pharmacological results (ED50 in mg/kg) obtained in rats from 17 reference neuroleptic compounds in the combined ATN test [48], 

The biplots show which binding tests are predictive for which pharmacological tests. Binding to the haloperidol and apomorphine labeled receptors corresponds with inhibition of agitation and stereotypy in rats, binding to the spiperone receptor 

Biochemical results (A , in nM) obtained in binding assays of radioactively labeled brain receptors [57] from the same 17 neuroleptics shown in Table 37.9. 

1 miorix NEO CLOZAPINE 1 FLIPHENAZINE CHLONPmmiXEMEO. -f C OL ZX O IopopenzoolO APONOmOME PENFLURZOOL 

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