Tunicamycin lipid

ST 13 fibroblasts maintained in a medium containing insulin differentiate into adipose-like cells. This conversion is characterized by the appearance of lipid droplets in the cytoplasm and by an increase in synthesis and accumulation of cellular triglyceride. The insulin binding increases about 10-fold during differentiation. Tunicamycin inhibits the differentiation and suppresses insulin-binding activity.551... 

Human-leukemic antigen (HLA-DR) has been found in remarkably low proportions on the plasma membrane of human, lymphoblastoid cells. In the presence of tunicamycin, both subunits of this cell-surface antigen showed lower apparent molecular weights. One of them completely lost its [3H]-labelled 2-acetamido-2-deoxy-D-glucose portion, implying that HLA-DR antigens possess oligosaccharides whose synthesis is lipid carrier-dependent.555... 

The liposidomycins are a family of novel lipid-containing nucleoside antibiotics that were found in the culture filtrate and mycelia of Streptomyces griseoporeus These antibiotics, which have unique biological activity and structures, inhibit the formation of the lipid intermediate in bacterial peptidoglycan synthesis three times more than does tunicamycin and have extremely high specificity. The structures of liposidomycins B (1) and C were proposed on the basis of degradation and spectroscopic studies. They are identical except for slight variations in the lipid portion. 

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