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Tumours, anti-tumour candidates

The Biginelli multi-component synthesis of 5-acyl dihydropyrimidin(thi)ones (117, X = S or O) from a (thio)urea, [H2N-C(=X)-NH2], an aldehyde (R -CHO) and a )5-ketoester (R -CO-CH2-CO-R ) has provided a wide range of anti-tumour candidates. " Using an ion-tagged iron catalyst - an imidazolium with FeC " or Fe2Cl7 as counterion - the reaction can be carried out under ionic liquid conditions. [Pg.40]

Although a number of the polyhydroxylated alkaloids have been reported to show anti-cancer activity, research has concentrated on developing swainsonine as a drug candidate for the management of human malignancies. Swainsonine has a complex mode of action in the whole animal. It inhibits the growth of tumour cells and prevents... [Pg.186]

See other pages where Tumours, anti-tumour candidates is mentioned: [Pg.36]    [Pg.214]    [Pg.268]    [Pg.587]    [Pg.165]    [Pg.285]    [Pg.291]    [Pg.251]    [Pg.283]    [Pg.219]    [Pg.90]    [Pg.321]   
See also in sourсe #XX -- [ Pg.40 ]



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Anti-tumour candidates

Candidates

Candide

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