Tumors study techniques

In reviewing intraarterial infusion of microencapsulated anticancer agents and its clinical applications, Nemoto (124) concluded that this mode of treatment can be used for a wide variety of tumors, providing remarkable therapeutic effects with minimal systemic toxicity. However, 25% of the treated tumors failed to respond, which was thought to be attributable to either inadequate catheterization, inadequate dose relative to tumor size, insufficient tumor vascularity, low drug sensitivity, or a combination of these factors. More carefully designed studies will be necessary before this technique is likely to meet with widespread acceptance. 

Second, it was shown that, if the porphyrin-containing tumor so produced was irradiated with a visible (or red) light source of moderate intensity, the photodynamic effect came into operation, and photonecrosis of the tumor ensued.19 Subsequent studies, particularly by Dougherty and his colleagues,20 demonstrated the clinical promise of the technique. 

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