Tumorigenic mutations

Tumorigenic mutations occur mainly in three regions involved in DNA binding... 

Figure 9.22 Most tumorigenic mutations of pS3 are found in the regions of the polypeptide chain that are involved in protein-DNA interactions. These regions are loops L2 (green) and L3 (red) and a region called LSH (blue) which comprises part of p strand 9 as well as the C-terminal a helix.

Cho, Y., et al. Crystal structure of a p53 tumor suppres-sor DNA complex understanding tumorigenic mutations. Science 265 346-355, 1994. 

POU regions bind to DNA by two tandemly oriented helix-turn-helix motifs Much remains to be learnt about the function of homeodomains in vivo Understanding tumorigenic mutations The monomeric p53 polypeptide chain is divided in three domains The oligomerization domain forms tetramers The DNA-binding domain of p53 is an antiparallel P barrel... 

Cho, Y, Gorina, S., Jeffrey, P.D. and Pavletich, N.P Crystal structure of a p53 tumor suppressor-DNA complex understandung tumorigenic mutations (1994) Science 265, 346-355... 

Cho Y, Gorina S, Jeffrey PD, Pavletich NP. Crystal stmcture of a p53 tumor suppressor-DNA complex understanding tumorigenic mutations. Science. 1994 265 346-55. 

Toxicology LDLo (oral, rat) 1500 mg/kg, (oral, mouse) 800 mg/kg, (subcut., mouse) 1200 mg/kg toxic mod. toxic by ing. and subcut. routes harmfui if inhaied or absorbed thru skin irritating to eyes, skin, mucous membranes, upper respiratory tract may cause aiiergic reactions, eczema of hands and arms experimental neoplastigen, carcinogen equivocal tumorigen mutation data TSCA listed... 

Toxicology LD50 (oral, rat) 65 mg/kg poison by ing. toxic by inh., skin contact acute oral, deadly poison to rats may cause weakness, tremors, cyanosis, drowsiness, dermatitis, convulsions, hematuria questionable carcinogen experimental tumorigen mutation data TSCA listed... 

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