Tumor targeting efficiency

Na JH, et al. Effect of the stability and deformabUity of self-assembled glycol chitosan nanopaiticles on tumor-targeting efficiency. J Control Release. 2012 163(l) 2-9. 

Poly(malic acid) is of pharmaceutical interest because its chemical derivatives may harbor both tissue-specific homing molecules and therapeutic effectors to be used for tissue (tumor) targeting in chemotherapy [2]. Because of its efficient production by fermentation, its biodegradability and nontoxicity, it is also considered as raw material in the industrial production of detergents, glues, and plastic materials. 

Maeda H, Bharate GY, Daruwalla J (2009) Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect. Eur J Pharm Biopharm 71 409 -19... 

Wei, Y., Pirollo, K.F., Yu, B., Rait, A., Xiang, L., Huang, W., Zhou, Q., Ertem, G., and Chang, E.H. (2004) Enhanced transfection efficiency of a systemically delivered tumor-targeting immunolipoplex by inclusion of a pH-sensitive histidylated oligolysine peptide. Nucleic Acids Res. 32 e48. 

Yang X, PUla S, Grafter JJ, Steeber DA, Gong S, Chen Y, Chen G (2009) Tumor-targeting, superparamagnetic polymeric vesicles as highly efficient MRI contrast probes. J Mater Chem... 

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