Tubular epithelial cell damage

Tubular epithelial cell damage Acute tubular necrosis Pentamidine... 

Renal tubular epithelial cell damage may be caused by either direct toxic or ischemic effects of drugs. Damage localizes in... 

Tubular epithelial cell damage Tubulointerstitial disease... 

The primary agents implicated in renal tubular epithelial cell damage... 

Ueda, N. and Shah, S.V. (1992). Endonuclease-induced DNA damage and cell death in oxidant injury to renal tubular epithelial cells. J. Clin. Invest. 90, 2593-2597. 

After peroral intake of nickel sulphate in mice, kidney damage appeared at the corticomedullary junction [296]. There was loss of renal tubular epithelial cells and protein loss, giving numerous hyaline casts in the renal tubules and collecting ducts, especially prominent in the renal papillae. 

The unique distribution of various enzymes along the length of the nephron provides the potential for identifying the specific injury site. Enzymes may not be uniformly distributed along or between nephrons thus the site selechvity of single enzymes is questionable, however it should be possible to localize the area of kidney damage on the basis of the pattern of enzymuria. While many urinary enzymes have been evaluated [169] as markers of damage or dysfunction of tubular epithelial cells [162,170], only a small number are considered to be valuable as biomarkers[152]. 

Walev I, Bhakdi S. Possible reason for preferential damage to renal tubular epithelial cells evoked by amphotericin B. Antimicrob Agents Chemother 1996 40 1116-20. 

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