Tryptophan decarboxylase dioxygenase

Figure 8.4. Pathways of tryptophan metaholism. Tryptophan dioxygenase, EC 1.13.11.11 formylkynurenine formamidase, EC 3.5.1.9 kynurenine hydroxylase, EC 1.14.13.9 kynureninase, EC 3.7.1.3 3-hydroxyanthranilate oxidase, EC 1.10.3.5 picolinate carboxylase, EC 4.1.1.45 kynurenine oxoglutarate aminotransferase, EC 2.6.1.7 kynurenine glyoxylate aminotransferase, 2.6.1.63 tryptophan hydroxylase, EC 1.14.16.4 and 5-hydroxytryptophan decarboxylase, EC 4.1.1.26. Relative molecular masses (Mr) tryptophan, 204.2 serotonin, 176.2 kynurenine, 208.2 3-hydroxykynurenine, 223.2 kynurenic acid, 189.2 xanthurenic acid, 205.2 and quinolinic acid 167.1. CoA, coenzyme A.

Fig. 244. Degradation of L-tryptophan via kynurenine and 3-hydroxyanthranilic acid 1 Tryptophan 2,3-dioxygenase (tryptophan pyrrolase, C 2.5) 2 formamidase 3 kynurenine 3-monooxygenase 4 kynureninase 5 3-hydroxyanthranilate 3,4-dioxygenase 6 aminocarhoxy-muconate semialdehyde decarboxylase 7 aminomuconate semialdehyde dehydrogenase 8 0x0-glutarate dehydrogenase system 9 spontaneous cyclization...

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