Tropine benzoate

Hyoscyamine (duboisine) and the racemate atropine are mACh-R antagonists and a number of atropine derivatives also have this property, namely anisodamine (6P-hydroxyhyoscyamine), 7 (3-hydroxyhyoscyamine, hyoscine (6,7-epoxyhyoscyamine or scopolamine), benzoyltropein (tropine benzoate), littorine (tropine a-hydroxyphenylpropionate), tigloidine (pseudotropane tiglate) and tropacocaine (pseudotropine benzoate). The further derivatives apoatropine (a-dehydrohyoscyamine) and tropine are very toxic. 

The stimulant narcotic cocaine (benzoylmethylecgonine) from Erythroxylum coca (coca) and other Erythroxylum species (Erythroxylaceae) inhibits serotonin (5HT) and dopamine reuptake. Related bioactive tropane alkaloids from Erythroxylum species include benzoylecgonine, benzoyltropeine (tropine benzoate), cinnamoylcocaine (cinnamoylmethylecgonine) and ecgonine. 

Tropacocaine. exo-ti-Methyl-8-azabicyclo[i.2.1 ]-octan-3-ol benzoate laltt5all-iropan-30-ol benzoate ben-zoylpseudotropeine benzoyl-d -tropeine pseudotropine benzoate -tropine benzoate tropacaine. mol wt... 

The bark of Erythroxylum ellipticum, a tall Australian tree that reaches a height of 35 feet, contains 0.32% crude alkaloids, from which tropine 3,4,5-trime-thoxycinnamate and tropine benzoate have been isolated (83). These alkaloids are derivatives of tropine (3a-hydroxytropane), thus differing from cocaine-type alkaloids in that the latter are pseudotropine (3)ff-hydroxytropane) derivatives. 

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