Trofosfamide

Chemical Name N,N,3-tris(2-chloroethyl)-tetrahvdro-2H-1,3,2-oxaphosphorin-2-amine-2-oxide 

N-bis-(2 hloroethyl)-phosphoric acid amide dichloride N-(2-ChloroethyI)-N-(3-hydroxypropyl)-amine hydrochloride Triethylamine 

259 g (1 mol) of N,N-bis-(2-chloroethyl)-phosphoric acid amide dichloride, 209 g (1.2 mols) of N-(2-chloroethvl)-N-(3-hvdroxypropvl)-amine hydrochloride (crude), 1,000 cc of ethylene 

---

Ivuacillin Ampicillin Ivualexin Cephalexin Ixoten Trofosfamide Izaberizin -Cinnarizine Izobarin Guanethidine sulfate... 

T.l.c.—A modified Jungnickel s reagent has been used for detecting phospholipids216 and other phosphorus compounds, and pyridine-4-aldehyde-2-benzothiazolylhydra-zone (PBH) is recommended for the quantitative determination of cyclophosphamide (175), ifosfamide, and trofosfamide.217 The chromatographic behaviour of... 

Another review covered metabolic studies on cylophosphamide, ifosfamide and trofosfamide. The analytical techniques covered were GC/MS, LC/MS and LC/MS/MS [67]. The same class of drugs has been determined in urine by GC/MS/MS with on-column injection and LC/MS/MS with LLE [68,69]. Chiral derivatisation has been used in conjunction with HPLC to measure the ratio of cyclophosphamide enantiomers [70]. 

D. Masurel and I. W. Wainer, Analytical and preparative high-performance liquid chromatographic separation of the enantiomers of ifosfamide, cyclophosphamide and trofosfamide and their determination in plasma ,. /. Chromatogr. 490 133-143 (1989). 

Trofosfamide, N,N,3-Tris(2-chloroethyl)tetrahy-dro-2H-l, 3,2-oxazaphosphorin-2-amine 2-Oxide 2-[bls(2-Chloroethyl)amino]-3-(2-chloroethyl)tetrahydro-2H-l,3,2-oxaphosphorine 2-oxide N.N.N -tris(2-chlOroethyl)-JV ,0-propylene phosphoric add ester diamide trilophosphamide trophosphamide NSC 109723 Z 4828 Ixoten. CJL.Cl,-NjOjP mol wt 323.56. C 33.41%, H 5.60%, Cl 32.87%, N... 

Cyclophosphamide is one of the most useful antineoplastic agents and substitution at C-4 position has led to 4-phenyl cyclophosphamide (a) and 4-methyl cyclophosphamide (b) The most commonly used analogues of cyclophosphamide are Ifosfamide (c) and Trofosfamide d) ... 

---