Tritiated water, formation granuloma

The data given in Table VI show that there was a considerable increase in formation of tritiated water upon in vitro addition of ascorbic acid. Addition of ascorbic acid failed to increase tritiated water for mation with minces of normal granuloma, and no effect was observed... 

Figure 3. Formation of tritiated water from tritiated proline by granuloma from normal and scorbutic guinea pigs...

It is conceivable that the reduced formation of tritiated water observed in scurvy could be due to a general reduction in protein synthesis, but this would not explain the marked differences between the specific activities of proline and hydroxyproline observed, nor would it explain observations in our laboratory that glycine and tyrosine are incorporated at rates similar to that of incorporation of proline into the collagen of granuloma obtained from scorbutic animals. 

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See also in sourсe #XX -- [ ]

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