Tritiated building blocks

H]Propionic acid 11191 is an additional example of a highly useful low molecular tritiated building block prepared by sp tritiodehalogenation. It is conveniently accessible at a specific activity of 18.9 Ci/mmol by 10% Pd/C catalyzed tritiolysis of 3-bromopropionic acid in the presence of triethylamine. Its applications include the synthesis of 2-(2,4-... 

H ]Methyl iodide (n=l or 3), the most common tritiated building block, has been extensively employed in various C-, N-, O- and 5-tritiomethylation reactions . ... 

A strategy to avoid a potentially hazardous release of highly tritiated volatile building blocks is to operate on nonvolatile derivatives from which they can be released as required. This is illustrated for high specific activity acetic acid and acetaldehyde by the catalytic tritiodehalogenation of derivatives 122 (X = Br —> and 123 (X = C1 —>... 

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