Triterpenoid glycosides principles

Cyclocarioside A (46) is a dammarane-type triterpenoid glycoside sweet principle from the leaves of Cyclocarya paliurus (Batal.) Iljinsk (Juglandaceae), a plant used in the People s Republic of China in the treatment for diabetes [81]. Recently, another sweet-tasting principle, cyclocarioside I (47), was isolated from the same plant along with two other compounds with the same dammarane-type triterpenoid aglycone structure [82]. Cyclocarioside I was rated as about 250 times sweeter than sucrose [82]. 

Ginseng may be derived from any of several species of the genus Panax. Of these, crude preparations or extracts of Panax ginseng, the Chinese or Korean variety, and P quinquefolium, the American variety, are most often available to consumers in the United States. The active principles appear to be the triterpenoid saponin glycosides called ginsenosides or panaxosides, of which there are approximately 30 different types. It is recommended that commercial P ginseng formulations be standardized to contain 4-7% ginsenosides. 

The active principles appear to be a dozen or more triterpenoid saponin glycosides called ginsenosides or panaxosides. It is recommended that commercial Panax ginseng formulations be standardized to contain 7% ginsenosides. 

These cucurbitane triterpenoids have been well known as bitter principles in Cucurbitaceous plants, but compound 114 had a strong sweet taste. The cytotoxic activities of several cucurbitane triterpenes have already been reported, but the anti-tumor-promoting activities of these triteijienoids have not been reported thus far. Therefore, there is quite a possibility that novel chemopreventive agents will be developed from cucurbitane glycosides. 

---