2.4.6- Trisubstituted dihydropyrimidines tautomerism

X-Ray analyses and solid-state IR spectra were recorded for a number of 1,4-and 1,6-dihydropyrimidines, demonstrating the dependency of the tautomeric composition in the crystal on the substitution in the pyrimidine ring and on the ability of these compounds to form intermolecular hydrogen bonds. Thus, 2,4,6-trisubstituted dihydropyrimidines exist in the solid state exclusively as 1,4-dihydro tautomers independently of the nature of the substituents (alkyl, aryl, heteroaryl, acyl, alkoxycarbonyl, etc.) [82H(19)493 86H(24)233 86T6429 90JMC1510]. Introduction of another alkyl substituent into the 4 position shifts the equilibrium toward the 1,6-dihydro isomer. For example, 2-phenyl-... 

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See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , ]

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