Trisoxazolines copper catalysts

Catalysis In a Tea Bag" with Dendrimer-lmmobilized Bis- and Trisoxazoline Copper Catalysts... 

Pseudo-C3-symmetrical trisoxazoline copper(II) complexes prove to be excellent catalysts in the Friedel-Crafts alkylation of indoles with alkylidene malonates (Eq. 7.13). Water tolerance of chiral catalyst trisoxazoline/Cu(OTf)2 was examined, and it was found that the addition of up to 200 equivalents of water relative to the catalyst in /,vo-butyl... 

Several pseudo-C3-symmetric homo- and hetero-trisoxazolines have been developed and applied successfully in the asymmetric Michael-type alkylation of indoles with alkylidene malonates. The C3-symmetric trisoxazoline 121a-copper(C104)2 -6H20 complex, as a catalyst, is an air- and water-stable compound (Scheme 34) [108-110]. 

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