Triplex-forming oligonucleotides

Vasquez, K.M., Narayanan, L. and Glazer, P.M. (2000) Specific mutations induced by triplex-forming oligonucleotides in mice. Science, 290, 530-533. 

Most effort thus far on artificial transcription factors has focused on the DNA binding domain (Fig. 5c). Several synthetic DNA binding molecules have been used. One approach is to recognize the double-stranded DNA, either with triplex forming oligonucleotides (143, 144) or with peptide nucleic acids... 

Kuznetsova S, et al. Gene activation by triplex-forming oligonucleotide coupled to the activating domain of protein VP16. Nucleic Acids Res. 1999 27 3995-4000. 

The bending of DNA has been studied by joining a pair of triplex forming oligonucleotides by a variable length linker. ... 

M. Faria, C. D. Wood, L. Perrouault, J. S. Nelson, A. Winter, M. R. H. White, C. Helene and C. Giovannangeli, Targeted inhibition of transcription elongation in cells mediated by triplex-forming oligonucleotides. Proceedings of the National Academy of Sciences USA, 97 (2000), 3862-3867. 

E. T. Kool, Design of triplex-forming oligonucleotides for binding DNA and RNA optimizing affinity and selectivity. New J. Chem., 21 (1997) 33 5. 

C. GiovannangeU, Targeted inhibition of transcription elongation in cells mediated by triplex-forming oligonucleotides. Proceedings of the National Academy of Sciences USA, 97 (2000), 3862-3867. 

Towards the sequence-selective recognition of double-stranded DNA containing pyrimidine-purine interruptions by triplex-forming oligonucleotides 12EJ02875. 

Whereas, previously, LNA has been primarily used in antisense-related applications, in the past year new applications have been described. The thermodynamic and hydration effects, as well as the effect of counterion on DNA octamers containing 1-3 LNA residues, have been examined. LNA Triplex-forming oligonucleotides have been used to target chromosomal sites, LNA has been used to stabilise the 5 -end of short primers for DNA sequencing and PCR, and a... 

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