Trimethoprim-sulfamethoxazole children

Murphy JL, Griswold WR, Reznik VM, Mendoza SA. Trimethoprim/sulfamethoxazole-induced renal tubular acidosis. Child Nephrol Urol 1990 10(l) 49-50. 

Woody RC, Brewster MA. Adverse effects of trimethoprim-sulfamethoxazole in a child with dihydropteridine reductase deficiency. Dev Med Child Neurol 1990 32(7) 639 2. 

Asmar BI, Maqbool S, Dajani AS. Hematologic abnormalities after oral trimethoprim-sulfamethoxazole therapy in children. Am J Dis Child 1981 135(12) 1100-3. 

Khaled A, Kharfi M, Fazaa B, Kourda M, Bouaziz A, Kastalli S, Kamoun MR. A first case of trimethoprim-sulfamethoxazole induced Sweet s syndrome in a child. Pediatr Dermatol 2009 26(6) 744—6. 

Auxier GG. Aseptic meningitis associated with administration of trimethoprim and sulfamethoxazole. Am J Dis Child 1990 144(2) 144-5. 

A child who was stable taking phenytoin and sultiame developed phenytoin toxicity within 48 hours of starting co-trimoxazole. Toxicity resolved when the antibacterial was changed to amoxicillin. A clinical study found that co-trimoxazole and trimethoprim can increase the phenytoin half-life by 39% and 51%, respectively, and decrease the mean metabolic clearance by 27% and 30%, respectively. Sulfamethoxazole alone had only a small effect on the half-life and did not affect the clearance of phenytoin. A case report describes fatal acute hepatic failure in a 60-year-old woman 10 days after starting co-trimoxazole and 14 days after starting phenytoin. This patient was also given cimetidine, which may raise phenytoin levels (see Phenytoin + H2-receptor antagonists , p.559). 

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